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Clinical Trials Support Letters

One of the roles of the RD at the MoPH is to review and approve clinical trials. The below table presents the trials that were approved since 2015:​

Clinical Trial Title
PI's Institution
Date of Approval
A randomized, multicenter, open-label cross-over study to evaluate patient preference and satisfaction of subcutaneous administration of the fixed-dose combination of Pertuzumab and Trastuzumab in patients with HER2-Positive early breast cancer
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HMC
08/07/2019
Effect of Combination Therapy with Dapagliflozin plus Low Dose Pioglitazone on Hospitalization Rate in Patients with Type 2 Diabetes Mellitus and Preserved Left Ventricular Ejection Fraction Heart Failure
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HMC
24/06/2019
A noninvasive monitor to predict hypoglycemia in diabetes patients
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WCM-Q
07/02/2019
The Efficacy and Safety of Ferriprox® for the Treatment of Transfusional Iron Overload in Patients with Sickle Cell Disease or Other Anemias
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HMC
14/03/2018
A Placebo Controlled Trial to Determine the Effect of Ischemic Perconditioning on Blood Flow in Collateral Circulation Distal to Proximal Occlusion in Acute Stroke Patients
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HMC
12/03/2018
A phase 4 open-label randomized controlled study comparing the effectiveness of adalimumab introduction and methotrexate dose escalation in subjects with Psoriatic arthritis (CONTROL)"
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HMC
26/02/2018
Evaluation of Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Septic Shock: an Open Label Randomized Control Trial
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HMC
19/02/2018
Use of dexamethasone in prevention of the second phase or a biphasic reaction of anaphylaxis
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HMC
19/02/2018
A Phase 3, Double-blind, Randomized, Placebo-controlled, Multicenter Study of GBT440 Administered Orally to Patients With Sickle Cell Disease
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HMC
01/08/2017
Antioxidants in male infertility: A clinical trial
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HMC
19/03/2017
A pilot study on benefits of Hijama cupping therapy in the treatment for Tinnitus, Sudden Sensory Neural Hearing Loss and Dizziness
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HMC
12/01/2017
Implantation of the Venus P Valve in the Pulmonic Position in Patients with Native Outflow Tracts
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Sidra Medicine
19/12/2016
Depression, Obesity and Inflammatory Markers (DOIM Study) - Aim 4
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WCM-Q
05/12/2016
Intervention using vitamin D for Elevated urinary Albumin in diabetes (IDEAL-2 Study)
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HMC
18/09/2016
Glucosuria Induced Increase in HGP: Basic Mechanisms and Clinical Implications. Protocol 1: Elucidation of The Mechanisms Responsible for the Increase in HGP in Response to Glucosuria. Protocol 3: Can GLP-1 Receptor Agonist, Exenatide, Prevent the Compensatory Increase in HGP in Response to Dapagliflozin and Produce Synergistic Reduction in Blood Sugar
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HMC
03/08/2016
A Phase 2, Multi-Center, Randomized, Double-blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of lulizumab pegol/BMS-931699 vs. Placebo on a Background of Limited Standard of Care in the Treatment of Subjects with Active Systemic Lupus Erythematosus
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HMC
02/08/2016
A Phase 3B, Randomized, Double-Blind Clinical Trial to Evaluate the Efficacy and Safety of Abatacept SC in Combination with Methotrexate Compared to Methotrexate Monotherapy in Achieving Clinical Remission in Adults with Early Rheumatoid Arthritis who are Methotrexate Naive
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HMC
02/08/2016
An Open-Label Study to Assess the Efficacy, Safety, Tolerability, and Pharmacokinetics of Multiple Doses of ISIS 396443 Delivered Intrathecally to Subjects With Genetically Diagnosed and Presymptomatic Spinal Muscular Atrophy / Nurture Study
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HMC
13/06/2016
A Phase III Randomized, Open-Label, Multi-Center, Global Study of MEDI4736 in Combination with Tremelimumab Therapy Versus Standard of Care Platinum-Based Chemotherapy in First Line Treatment of Patients with Advanced or Metastatic Non Small-Cell Lung Cancer (NSCLC) / NEPTUNE study
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HMC
30/05/2016
Multicenter randomized, open label, non-inferiority active-controlled trial to evaluate the efficacy and safety of deferiprone compared to deferasirox in pediatric patients aged from 1 month to less than 18 years affected by transfusion dependent haemoglobinopathies / DEEP-2 study
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HMC
23/05/2016
An Open-Label, Multicenter Study to Evaluate Long-Term Outcomes With ABT-450/Ritonavir/ABT-267 (ABT-450/r/ABT-267) and ABT-333 With or Without Ribavirin (RBV) in Adults With Genotype 1 Chronic Hepatitis C Virus (HCV) Infection (TOPAZ-I)
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HMC
04/01/2016
Does glycated hemoglobin variability in type 2 diabetes differ depending on the diabetes treatment used in the Qatari population: implication on diabetes complication risk
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WCM-Q
27/12/2015
Diabetes Intervention Accentuating Diet and Enhancing Metabolism (Diadem-I): A Randomised Controlled Trial Assessing The Impact of Low Calorie Diet and Activity on Body Weight and Glycaemia in Diabetes in Early Diabetes
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WCM-Q
27/12/2015
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